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Merck
CN
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文件

安全信息

925047

Sigma-Aldrich

KB02-COOH

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别名:
2-((1-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetic acid, Functionalized scout fragment
经验公式（希尔记法）:
C13H14ClNO4
CAS号:
2375196-30-6
分子量:
283.71
NACRES:
NA.22

反应适用性

reagent type: chemical modification reagent

质量水平

100

储存温度

2-8°C

应用

KB02-COOH is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include cysteine fragment KB02 (912131), KB02-SLF (914738), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Technology spotlight: Proteomic Ligandability Assessment

其他说明

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Xiaoyu Zhang et al.
Nature chemical biology, 15(7), 737-746 (2019-06-19)
Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process. Here, we use a chemical proteomic

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