所有图片(1)

主要文件

COO原产地证书/COA分析证书

查看所有文档

安全信息

安全和法规

921327

C5 Lenalidomide-PEG₆-Butyl NH₂ hydrochloride

Name: C5 Lenalidomide-PEG<SUB>6</SUB>-Butyl NH<SUB>2</SUB> hydrochloride
Brand: ALDRICH

≥95%

别名:

24-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-3,6,9,12,15,18-hexaoxatetracosanamide hydrochloride, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₃₁H₄₈N₄O₁₀ · xHCl

分子量:

636.73 (free base basis)

MDL编号:

MFCD34549914

NACRES:

NA.22

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

911704

C5 Lenalidomine-C₃-NH₂ hydrochloride

Sigma-Aldrich

794333

聚 [2,6′]-4,8-二（5-乙基己基噻吩）苯并 [1,2-b;3,3-b] 二噻吩 ] {3-氟-2 [（2-乙基己基）羰基] 噻吩 [3,4-b] 噻吩二基 }）

Sigma-Aldrich

CIX001

ComInnex IAP Ligand Library

Sigma-Aldrich

920797

C5 Lenalidomide-pyridine-PEG₁-piperazine hydrochloride

Sigma-Aldrich

917206

A1V2PF1-NHEt-C₁₀-NH₂

Sigma-Aldrich

923931

Pomalidomide-4-piperidine-C₁-piperazine hydrochloride

Sigma-Aldrich

923443

PhMPhos

Sigma-Aldrich

445703

聚(3-己基噻吩-2,5-二基)

Sigma-Aldrich

660485

3,4-亚丙基二氧噻吩

Sigma-Aldrich

920827

(S,R,S)-AHPC-methylamino-PEG₁-NH₂ hydrochloride

ligand

C5 Lenalidomide

质量水平

100

方案

≥95%

表单

powder or crystals

反应适用性

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

官能团

amine

储存温度

2-8°C

SMILES字符串

O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCOCCCCCCN)=O)=CC=C31.Cl

InChI

1S/C31H48N4O10.ClH/c32-9-3-1-2-4-10-40-11-12-41-13-14-42-15-16-43-17-18-44-19-20-45-23-29(37)33-25-5-6-26-24(21-25)22-35(31(26)39)27-7-8-28(36)34-30(27)38;/h5-6,21,27H,1-4,7-20,22-23,32H2,(H,33,37)(H,34,36,38);1H

InChI key

GDNQKCBPUXQOGD-UHFFFAOYSA-N

应用

Protein degrader builiding block C5 Lenalidomide-PEG6-Butyl NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a PEGylated linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight:Degrader Building Blocks for Targeted Protein Degradation

Portal:Building PROTAC^® Degraders for Targeted Protein Degradation

其他说明

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Targeted Protein Degradation by Small Molecules.

Daniel P Bondeson et al.

Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)

Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of

Impact of linker length on the activity of PROTACs.

Kedra Cyrus et al.

Molecular bioSystems, 7(2), 359-364 (2010-10-06)

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

商品

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

主要文件

安全信息

C5 Lenalidomide-PEG6-Butyl NH2 hydrochloride

≥95%

About This Item

推荐产品

属性

ligand

质量水平

方案

表单

反应适用性

官能团

储存温度

SMILES字符串

InChI

InChI key

相关类别

说明

应用

其他说明

法律信息

相关产品

相关产品

安全信息

储存分类代码

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

已有该产品？

同行评审论文

技术文章和实验方案

商品

技术服务

C5 Lenalidomide-PEG₆-Butyl NH₂ hydrochloride