表单
powder
质量水平
反应适用性
reagent type: linker
官能团
Boc
carboxylic acid
储存温度
2-8°C
SMILES字符串
CC(C)(OC(N1CC(C2=CN=C(C(O)=O)C=N2)C1)=O)C
InChI
1S/C13H17N3O4/c1-13(2,3)20-12(19)16-6-8(7-16)9-4-15-10(5-14-9)11(17)18/h4-5,8H,6-7H2,1-3H3,(H,17,18)
InChI key
UMVYLQZBFNQMPM-UHFFFAOYSA-N
应用
5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920487
920495
920576
ADV638390284
Similar linkers in this series:
920487
920495
920576
ADV638390284
其他说明
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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