91917
5,5,5-三氟-DL-亮氨酸
≥98.0% (sum of isomers, HPLC)
别名:
(±)2-氨基-4-(三氟甲基)戊酸
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关于此项目
经验公式（希尔记法）:
C6H10F3NO2
化学文摘社编号:
分子量:
185.14
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22
MDL number:
SMILES string
CC(CC(N)C(O)=O)C(F)(F)F
InChI key
XFGVJLGVINCWDP-UHFFFAOYSA-N
InChI
1S/C6H10F3NO2/c1-3(6(7,8)9)2-4(10)5(11)12/h3-4H,2,10H2,1H3,(H,11,12)
assay
≥98.0% (sum of isomers, HPLC)
form
crystals
reaction suitability
reaction type: solution phase peptide synthesis
application(s)
peptide synthesis
Quality Level
General description
5,5,5-Trifluoro-DL-leucine, also known as trifluoroleucine, is an analog of L-leucine amino acid, often used to synthesize highly fluorinated peptides.
Application
5,5,5-trifluoroleucine can be incorporated into the coiled-coil peptides to increase their thermal stability.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
I Bardazzi et al.
Folia microbiologica, 49(5), 534-538 (2005-02-11)
Two new plasmids, pEC3 and pECkan, were constructed and their use in yeast transformation described. Both plasmids are derivative of the pRS416 vector, in which the URA3 auxotrophic marker was replaced by the LEU4* gene (pEC3) or the kanMX4 gene
Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine
Y Tang
Biochemistry, 40, 2790-2796 (2001)
Biosynthesis and stability of coiled-coil peptides containing (2S,4R)-5,5,5-trifluoroleucine and (2S,4S)-5,5,5-trifluoroleucine.
Jin Kim Montclare et al.
Chembiochem : a European journal of chemical biology, 10(1), 84-86 (2008-12-19)
J T Mulligan et al.
Journal of bacteriology, 151(2), 609-619 (1982-08-01)
Fusions of the lac genes to the promoters of four structural genes in the methionine biosynthetic pathway, metA, metB, metE, and metF, were obtained by the use of the Mu d(Ap lac) bacteriophage. The levels of beta-galactosidase in these strains
E Casalone et al.
Yeast (Chichester, England), 16(6), 539-545 (2000-05-03)
The function of the open reading frame (ORF) YOR108w of Saccharomyces cerevisiae has been analysed. The deletion of this ORF from chromosome XV did not give an identifiable phenotype. A mutant in which both ORF YOR108w and LEU4 gene have
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