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COO原产地证书/COA分析证书

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安全和法规

917184

BocA1V1PF2-OC₁₀-NH₂ hydrochloride

Name: BocA1V1PF2-OC<SUB>10</SUB>-NH<SUB>2</SUB> hydrochloride
Brand: ALDRICH

别名:

10-Aminodecyl (S)-2-((S)-1-((S)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate hydrochloride, AVP conjugate for IAP-mediated protein degrader development, SNIPER building block

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About This Item

经验公式（希尔记法）:

C₃₈H₆₂FN₅O₇ · xHCl

分子量:

719.93 (free base basis)

MDL编号:

MFCD34602188

UNSPSC代码:

41116105

NACRES:

NA.22

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Sigma-Aldrich

917435

BocA1V1PF2-OPEG₁-NH₂hydrochloride

Sigma-Aldrich

415952

(2,4,6-三甲基苯甲酰基)二苯基氧化膦

Sigma-Aldrich

475629

聚(乙二醇)二丙烯酸酯

Sigma-Aldrich

511447

苯基双（2,4,6-三甲基苯甲酰）氧化膦

Sigma-Aldrich

916927

BocA1V1PF2-OC₆-NH₂ hydrochloride

Sigma-Aldrich

SML0559

LDN193189 盐酸盐

Sigma-Aldrich

455008

聚(乙二醇)二丙烯酸酯

Sigma-Aldrich

448869

壳聚糖

Sigma-Aldrich

917710

A1V1PF2-OEt

Sigma-Aldrich

900738

PbS核型量子点

ligand

BocA1V1PF2

质量水平

100

表单

powder

反应适用性

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

官能团

amine

储存温度

2-8°C

SMILES字符串

C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCCCCCCCCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl

InChI

1S/C38H62FN5O7.ClH/c1-26(41-36(49)51-38(5,6)7)32(45)43-31(37(2,3)4)34(47)44-23-16-17-30(44)33(46)42-29(25-27-18-20-28(39)21-19-27)35(48)50-24-15-13-11-9-8-10-12-14-22-40;/h18-21,26,29-31H,8-17,22-25,40H2,1-7H3,(H,41,49)(H,42,46)(H,43,45);1H/t26-,29-,30-,3

InChI key

RUPLAKBBVZSRKK-YOHNHNBXSA-N

应用

Protein degrader building block BocA1V1PF2-OC₁₀-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology.

Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^® degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
917478 BocA1V1PF2
916927 BocA1V1PF2-OC₆-NH₂ hydrochloride
917184 BocA1V1PF2-OC₁₀-NH₂ hydrochloride
917435 BocA1V1PF2-OPEG₁-NH₂ hydrochloride
917680 BocA1V1PF2-OPEG₃-NH₂ hydrochloride

其他说明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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SNIPERs-Hijacking IAP activity to induce protein degradation.

Mikihiko Naito et al.

Drug discovery today. Technologies, 31, 35-42 (2019-06-16)

The induction of protein degradation by chimeric small molecules represented by proteolysis-targeting chimeras (PROTACs) is an emerging approach for novel drug development. We have developed a series of chimeric molecules termed specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein

Nobumichi Ohoka et al.

The Journal of biological chemistry, 292(11), 4556-4570 (2017-02-06)

Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach that may have utility in drug development relies

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.

Tasuku Ishida et al.

SLAS discovery : advancing life sciences R & D, 26(4), 484-502 (2020-11-05)

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new modality of chemical tools and potential therapeutics to understand and treat human disease. A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to

商品

Accelerating Protein Degrader Discovery with IAP

Plate of 80 ligands against E3 ligase IAP designed by ComInnex; allows creation of bifunctional targeted protein degraders or molecular glues.

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BocA1V1PF2-OC10-NH2 hydrochloride

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表单

反应适用性

官能团

储存温度

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InChI

InChI key

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储存分类代码

WGK

闪点(°F)

闪点(°C)

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分析证书(COA)

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BocA1V1PF2-OC₁₀-NH₂ hydrochloride