914746
Thiophosphoro alkyne dichloridate
≥95%
别名:
O-(Prop-2-yn-1-yl) phosphorodichloridothioate, Chemoselective histidine labeling reagent, Phosphorodichloridothioate 2-propyn-1-ol, Propargyl thiophosphorodichloridate, TPAC, Thiophosphoro alkyne dichloridate, Thiophosphorodichloridate reagent, Thiophosphorus electrophile
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About This Item
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质量水平
方案
≥95%
表单
liquid
储存温度
−20°C
SMILES字符串
[P](=S)(Cl)(Cl)OCC#C
InChI
1S/C3H3Cl2OPS/c1-2-3-6-7(4,5)8/h1H,3H2
InChI key
HPJLQEFYLAALCL-UHFFFAOYSA-N
应用
Thiophosphoro alkyne dichloridate (TPAC) is a histidine labeling reagent developed by the Chang lab that mimics native post-translational His phosphorylation. The alkyne allows for subsequent reactions or addition of payloads by copper-assisted alkyne-azide cycloaddition (CuAAC) chemistry. TPAC was also demonstrated to covalently modify His-tags, and by clicking on polyarginine tags, enabled protein delivery into live cells.
储存分类代码
10 - Combustible liquids
闪点(°F)
175.8 °F
闪点(°C)
79.9 °C
Shang Jia et al.
Journal of the American Chemical Society, 141(18), 7294-7301 (2019-04-25)
Site-selective bioconjugation to native protein residues is a powerful tool for protein functionalization, with cysteine and lysine side chains being the most common points for attachment owing to their high nucleophilicity. We now report a strategy for histidine modification using
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