914487
2-(Diphenylphosphanyl)benzamide
≥95%
别名:
2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
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关于此项目
经验公式（希尔记法）:
C19H16NOP
化学文摘社编号:
分子量:
305.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
产品名称
2-(Diphenylphosphanyl)benzamide, ≥95%
InChI key
IHGZKYLRNBICEF-UHFFFAOYSA-N
InChI
1S/C19H16NOP/c20-19(21)17-13-7-8-14-18(17)22(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,20,21)
SMILES string
P(c3c(cccc3)C(=O)N)(c2ccccc2)c1ccccc1
assay
≥95%
form
powder
storage temp.
−20°C
Quality Level
Application
2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).
General description
It is recommended to make fresh stock stolutions prior to each use.
存储类别
11 - Combustible Solids
wgk
WGK 3
Shao-Ru Wang et al.
Nature communications, 11(1), 91-91 (2020-01-05)
Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR
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