形式
powder
分子量
average Mn ~8,400
颜色
off-white to yellow
储存温度
−20°C
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应用
Poloxamers are nonionic, triblock copolymers containg a central hydrophobic chain of poly(propylene glycol) (PPG) and two terminal hydrophilic chains of poly(ethylene glycol) (PEG). Due to their amphiphilic structure, poloxamer solutions feature temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature, in a reversible process. This characteristic has allowed for these materials to be used as drug carriers for most routes of administration including oral, topical, intranasal, ocular, and parenteral. Acrylate-modified derivatives are most commonly used as thermosensitive hydrogels for drug delivery and 3D bioprinting applications. After casting or printing, the material can be crosslinked to preserve the hydrogel structure.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Smart hydrogels for 3D bioprinting.
Shuai W, et al.
International Journal of Bioprinting, 1(1), 3-14 (2015)
Self-Assembly of Pluronic F127 Diacrylate in Ethylammonium Nitrate: Structure, Rheology, and Ionic Conductivity before and after Photo-Cross-Linking.
Carlos R L, wt al.
Macromolecules, 49(14), 5179-5189 (2016)
Application of thermoreversible pluoronic F-127 gels in Pharmaceutical formulations.
Escobar-Chavez J J, et al.
J. Pharm. Pharm. Sci., 9(3), 339-358 (2006)
Christopher J Hansen et al.
Advanced materials (Deerfield Beach, Fla.), 25(1), 96-102 (2012-10-31)
Microvascular multinozzle arrays are designed and fabricated for high-throughput printing of functional materials. Ink-flow uniformity within these multigeneration, bifurcating microchannel arrays is characterized by computer modeling and microscopic particle image velocimetry (micro-PIV) measurements. Both single and dual multinozzle printheads are
Photopolymerization of Pluronic F127 diacrylate: a colloid-templated polymerization.
Manuela D B, et al.
Soft Materials, 7, 4928-4937 (2011)
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