推荐产品
产品名称
Acetylated branched polyethylenimine solution 20% solution, 20% acetylation, suitable for biomedical research
质量水平
表单
liquid
浓度
20 wt. % in water
颜色
pale yellow to yellow
储存温度
2-8°C
应用
High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo. N-Acetylation of PEI could lower its toxicity. At low degree of substitution (below 25%) resulted in moderate improvement of transfection activity.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
Nathan P Gabrielson et al.
Biomacromolecules, 7(8), 2427-2435 (2006-08-15)
We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine (PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride. In the present work, we investigated the effects of further increasing the degree of
M Laird Forrest et al.
Pharmaceutical research, 21(2), 365-371 (2004-03-23)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating
Arkadi Zintchenko et al.
Bioconjugate chemistry, 19(7), 1448-1455 (2008-06-17)
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of
商品
CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门