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壳聚糖具有优良的生物学特性，已广泛应用于药物递送和组织工程中。壳聚糖由于其带正电荷，具有良好的粘膜粘附性能，增加了对粘膜的粘连，有利于药物渗透。此外，壳聚糖具有止血性能，这使其成为伤口敷料应用的良好候选者。
伯胺的季铵化增加了壳聚糖的水溶性，并使壳聚糖在较宽的pH值范围内保持可溶性。在全部季铵化壳聚糖中，N, N, N-三甲基壳聚糖氯化物（TMC）在生物医学中的应用最为广泛。
伯胺的季铵化增加了壳聚糖的水溶性，并使壳聚糖在较宽的pH值范围内保持可溶性。在全部季铵化壳聚糖中，N, N, N-三甲基壳聚糖氯化物（TMC）在生物医学中的应用最为广泛。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
BOONYO W, et al.
Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
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Polymer Science (2011)
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A B Sieval, et al.
Carbohydrate Polymers, 36, 157-165 (1998)
J H Hamman et al.
Drug development and industrial pharmacy, 29(2), 161-172 (2003-03-22)
N-trimethyl chitosan chloride (TMC) is a polycation that enhances drug transport across epithelia by opening tight junctions. The degree of quaternization of TMC determines the number of positive charges available on the molecule for interactions with the negatively charged sites
Amir K Varkouhi et al.
Bioconjugate chemistry, 21(12), 2339-2346 (2010-11-06)
N,N,N-Trimethylated chitosan (TMC) is a biodegradable polymer emerging as a promising nonviral vector for nucleic acid and protein delivery. In the present study, we investigated whether the introduction of thiol groups in TMC enhances the extracellular stability of the complexes
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