检测方案
≥95%
形式
powder
反应适用性
reagent type: catalyst
reaction type: Cross Couplings
mp
235-248 °C
SMILES字符串
Cl[Ni]1(P(C(C2)(O3)C)(C4=CC=CC=C4P(C5=CC=CC=C5)1C6=CC=CC=C6)[C@@](C[C@]3(OC27C)C)(O7)C)C(C=CC=C8)=C8C
应用
PhPAd-DalPhos Ni(o-tolyl)Cl is an air stable precatalyst developed in the Stradiotto lab used for coupling of bulky primary amines with arenes.
警示用语：
Danger
危险分类
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Muta. 2 - Repr. 2 - Resp. Sens. 1 - STOT RE 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Joseph P Tassone et al.
Angewandte Chemie (International ed. in English), 58(8), 2485-2489 (2019-01-04)
The base metal-catalyzed C-N cross-coupling of bulky α,α,α-trisubstituted primary alkylamines with (hetero)aryl electrophiles represents a challenging and under-developed class of transformations that is of significant potential utility, including in the synthesis of lipophilic active pharmaceutical ingredients. Herein, we report that
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