911429
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA average Mn 5,000, lactide:glycolide 80:20
别名:
PEG-PLGA, PEG5K-PLGA5K, Polyethylene glycol, mPEG-b-PLGA
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所有图片(1)
About This Item
线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC代码:
12352112
NACRES:
NA.23
形式
powder
投料比
lactide:glycolide 80:20
分子量
PEG average Mn 5,000 (by NMR)
PLGA average Mn 5,000 (by NMR)
杂质
≤500 ppm (GC)
颜色
white
储存温度
−20°C
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应用
This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
商品
Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
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