检测方案
≥95%
形式
powder or crystals
反应适用性
reagent type: reductant
mp
249-256 °C
储存温度
−20°C
InChI
1S/C6H12NO3Si/c1-4-8-11-9-5-2-7(1)3-6-10-11/h1-6H2
InChI key
XBRVPWBNRAPVCC-UHFFFAOYSA-N
应用
1-Hydrosilatrane is an air- and moisture-stable hydride reducing reagent that exhibits high functional group compatibility. The Adler group has used 1-hydrosilatrane for the reduction of ketones and aldehydes as well as the direct reductive amination of ketones under mild conditions.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
1-Hydrosilatrane: A Locomotive for Efficient Ketone Reductions.
Varjosaari E S, et al.
European Journal of Organic Chemistry, 2017(2), 229-232 (2017)
Vladislav Skrypai et al.
The Journal of organic chemistry, 84(9), 5021-5026 (2019-04-12)
The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Brønsted acid catalyst is reported. This is the first known example of chiral Brønsted acid-catalyzed asymmetric reductive amination using a silane as the hydride
Silatrane as a Practical and Selective Reagent for the Reduction of Aryl Aldehydes to Benzylic Alcohols.
Skrypai V, et al.
European Journal of Organic Chemistry, 2016(12), 2207- 2211 (2016)
商品
As a versatile hydride reagent, 1-hydrosilatrane can be used in reduction reactions to synthesize alcohols, amines, their chiral counterparts, and esters from aldehydes/ketones.
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