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描述
suitable for 3D bioprinting applications
形式
gel form (Viscous)
杂质
≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden (Total Aerobic)
颜色
colorless to pale yellow
pH值（酸碱度）
6.5-7.5
应用
3D bioprinting
储存温度
2-8°C
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相关类别
一般描述
3D bioprinting is the printing of biocompatible materials, cells, growth factors, and the other supporting materials necessary to yield functional complex living tissues. 3D bioprinting has been used to generate several different types of tissue such as skin, bone, vascular grafts, and cartilage structures. Based upon the desired properties, different materials and formulations can be used to generate both hard and soft tissues. While several 3D printing methods exist, due to the sensitivity of the materials used, extrusion-based methods with bioinks are most commonly employed.
应用
Gelatin methacrylate-Alginate bioink formulation is derived from natural polymers - gelatin and alginate. Gelatin contains bioactive peptide sequences similar to native extracellular matrix which promotes integrin mediated cell adhesion and MMP sensitive enzymatic degradation which are essential for cellular functions such as migration, proliferation and differentiation. Alginate is a natural polysaccharide widely used in tissue engineering, serves as a viscosity enhancer in the bioink formulation. TissueFab®- GelAlg-Vis bioink formulation is optimized for 3D bioprinting of tissues and constructs using any extrusion based 3D bioprinter. TissueFab® - GelAlg-Vis bioink formulation can be used to bioprint cell-laden hydrogels in desired shape and can be crosslinked by a combination of chemical crosslinking and visible light mediated photocrosslinking for further culture and maturation of cells for tissue engineering and regenerative medicine applications. Gelatin methacrylate bioinks have been used for 3D bioprinting with high printing resolution, shape fidelity and cell viability. Gelatin methacrylate based bioinks have been used to bioprint osteogenic, chondrogenic, hepatic, adipogenic, vasculogenic, epithelial, endothelial, cardiac valve, skin, tumor and other tissues and constructs. Gelatin and alginate containing bioinks have been used for bioprinting of 3D constructs with various cell types including human mesenchymal stem cells (hMSC), embryonic stem cells (ESC), human umbilical vein endothelial cells (HUVEC), fibroblasts, cancer cells etc.
包装
10 mL in glass bottle
法律信息
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1 - STOT RE 2
靶器官
Liver,Upper respiratory tract
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Liliang Ouyang et al.
Biofabrication, 8(3), 035020-035020 (2016-09-17)
3D cell printing is an emerging technology for fabricating complex cell-laden constructs with precise and pre-designed geometry, structure and composition to overcome the limitations of 2D cell culture and conventional tissue engineering scaffold technology. This technology enables spatial manipulation of
Y Shi et al.
Biomedical materials (Bristol, England), 13(3), 035008-035008 (2018-01-09)
Three-dimensional bioprinting is an emerging technology for fabricating living 3D constructs, and it has shown great promise in tissue engineering. Bioinks are scaffold materials mixed with cells used by 3D bioprinting to form a required cell-laden structure. In this paper
Wanjun Liu et al.
Advanced healthcare materials, 6(12) (2017-05-04)
Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly
B Duan et al.
Acta biomaterialia, 10(5), 1836-1846 (2013-12-18)
Tissue engineering has great potential to provide a functional de novo living valve replacement, capable of integration with host tissue and growth. Among various valve conduit fabrication techniques, three-dimensional (3-D) bioprinting enables deposition of cells and hydrogels into 3-D constructs
Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering.
Birgit Huber et al.
Journal of biomaterials applications, 30(6), 699-710 (2015-05-29)
In vitro engineering of autologous fatty tissue constructs is still a major challenge for the treatment of congenital deformities, tumor resections or high-graded burns. In this study, we evaluated the suitability of photo-crosslinkable methacrylated gelatin (GM) and mature adipocytes as components
商品
生物墨水可3D生物打印形成功能组织结构，从而应用于药物筛选、疾病建模和体外移植。针对特定组织工程应用选择生物墨水和打印方法。
Bioinks enable 3D bioprinting of tissue constructs for drug screening and transplantation; select suitable bioinks for specific tissue engineering.
Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.
实验方案
Frequently asked questions (FAQs) for KAPA SYBR® FAST One-Step qRT-PCR Kits.
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