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Merck
CN
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文件

902551

Sigma-Aldrich

BocNH-PEG4-acid

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别名:
2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH
经验公式（希尔记法）:
C15H29NO8
CAS号:
876345-13-0
分子量:
351.39
UNSPSC代码:
12352106
NACRES:
NA.22

形式

liquid

反应适用性

reaction type: Pegylations
reagent type: cross-linking reagent

折射率

n/D 1.4641

密度

1.1395 g/mL

官能团

Boc
amine
carboxylic acid

储存温度

−20°C

SMILES字符串

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

相关类别

应用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

其他说明

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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