描述
16 NHBoc, 1 thiol (core)
形式
solid
分子量
generation 4
表面基团编号
16
颜色
white to off-white
官能团
thiol (core)
储存温度
−20°C
一般描述
- Polymer architecture: Dendron
- End Group Functionality: Boc-protected amine
- Boc: tert-Butyloxycarbonyl
- Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid
应用
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the thiol-core can be readily conjugated via a thiol-ene click reaction, Michael addition reactions, or disulfide exchange.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
商品
Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.
Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).
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