形式
crystals
质量水平
投料比
lactide:glycolide 50:50
分子量
PEG average Mn 5,000
PLGA Mn 15,000
杂质
≤5000 ppm (GC)
储存温度
−20°C
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一般描述
通过GC分析含有≤500 ppm的杂质，包括痕量的单体及残留有机物。
应用
生物相容性嵌段共聚物。可用于形成用于药物传递的纳米颗粒。具有用于癌症药物、抗炎药、抗生素或麻醉剂的靶向或受控释放的潜力。
WGK
WGK 3
闪点(°F)
>230.9 °F
闪点(°C)
> 110.5 °C
法规信息
新产品
Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
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