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Merck
CN

900757

Sigma-Aldrich

Sodium pyridine-2-sulfinate

别名:

2-Pyridinesulfinic acid, Sodium salt, Willis 2-pyridylsulfinates H

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About This Item

经验公式(希尔记法):
C5H4NNaO2S
CAS号:
分子量:
165.15
UNSPSC代码:
12352101
NACRES:
NA.22

形式

powder or crystals

质量水平

反应适用性

reaction type: C-C Bond Formation

mp

292 °C

InChI

1S/C5H5NO2S.Na/c7-9(8)5-3-1-2-4-6-5;/h1-4H,(H,7,8);/q;+1/p-1

InChI key

HQCGASCBCQJRDJ-UHFFFAOYSA-M

应用

This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

象形图

Corrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Skin Corr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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商品

Description: Professor Willis and partners at Pfizer have shown with pyridine-2- sulfinates a palladium-catalyzed desulfinylative cross-coupling process can be realized.

相关内容

Research in the Willis group is focused on the development of new catalysts and reactions for synthetic chemistry. The group is particularly interested in addressing synthetic challenges that are applicable to the pharmaceutical and agrochemical industries.

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