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质量水平
形式
powder
分子量
PCL average Mn ~2,000
PEG average Mn ~2,000
转变温度
flash point >230 °F
Tm 47-51 °C
储存温度
2-8°C
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应用
由亲水性PEG嵌段和疏水性PCL嵌段组成的生物相容性两亲嵌段共聚物。这些材料已被用作嵌段共聚物表面活性剂并在药物递送应用中用作控释和纳米颗粒制剂。可通过控制每个聚合物嵌段的相对长度来制备具有各种属性的定义明确材料。羟基封端可实现对这些材料进行进一步的化学修饰。
WGK
WGK 3
闪点(°F)
>230.0 °F
闪点(°C)
> 110 °C
On the mechanism of formation of vesicles from poly(ethylene oxide)-block-poly(caprolactone) copolymers.
Adams DJ, et al.
Soft Matter, 5, 3086-3096 (2009)
Xu Wen Ng et al.
Journal of pharmaceutical sciences, 103(11), 3631-3640 (2014-09-17)
Despite the success that drug-eluting stents (DESs) have achieved for minimizing in-stent restenosis (ISR), the antirestenotic agents used in DES have been implicated in delayed endothelial healing and impairment of endothelial functions. Cenderitide (CD-NP) is a novel antiproliferation chimeric peptide
Xu Wen Ng et al.
Drug delivery and translational research, 5(5), 469-479 (2015-06-24)
Timolol maleate (TM) has been used for many years for the reduction of intraocular pressure (IOP) in glaucoma patients. However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage
Simple solvothermalsynthesis of hydrophobic magnetic monodispersed Fe3O4 nanoparticles.
Liu J, et al.
Mat. Res. Bul., 48(2), 416-421 (2013)
Bhuvana S Doddapaneni et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 503-514 (2015-11-19)
Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease. Current treatment is surgery followed by radiation and intravenous chemotherapy. However, drawbacks for current chemotherapeutics lie in the fact that they develop resistance and do not
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The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
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