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安全信息

900605

Sigma-Aldrich

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

别名:

Bromo sulfonyl fluoride alkyne, Probe building block

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About This Item

经验公式（希尔记法）:
C12H14BrFO2SSi
CAS号:
2088829-12-1
分子量:
349.29
MDL编号:
MFCD30737997
UNSPSC代码:
12352200
NACRES:
NA.22

质量水平

100

方案

≥95%

表单

solid

反应适用性

reaction type: click chemistry

储存温度

−20°C

SMILES字符串

[Si](C)(C)(C)C#Cc1cc(cc(c1)CBr)[S](=O)(=O)F

InChI

1S/C12H14BrFO2SSi/c1-18(2,3)5-4-10-6-11(9-13)8-12(7-10)17(14,15)16/h6-8H,9H2,1-3H3

InChI key

QSYGHPYMWBAJRL-UHFFFAOYSA-N

相关类别

应用

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

其他说明


Technology Spotlight: Trifuctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCK8850
MKCC5121

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Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

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