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Merck
CN
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文件

900285

Sigma-Aldrich

MCAT-53™

greener alternative
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别名:
Ru2Cl2(p-cymene) (HCOO)2 • HCOONa, Ru2Cl2(p-cymene) (HCOO)3Na, Sodium η-6-p-cymene dichloro diruthenium (II, III) triformato complex
经验公式（希尔记法）:
C13H17Cl2NaO6Ru2
分子量:
565.31
UNSPSC代码:
12352200
PubChem化学物质编号:
329769798
NACRES:
NA.22

形式

powder

反应适用性

core: ruthenium
reaction type: Cross Couplings
reagent type: catalyst
reaction type: C-H Activation

环保替代产品特性

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Catalysis
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

247.8 °C

环保替代产品分类

, Aligned

储存温度

2-8°C

SMILES字符串

C[Ru]OC([H])=O.[Ru]OC([H])=O.ClC.CC.CC1=CC=C(C(C)C)C=C1.COC([H])=O.Cl.[Na]

InChI

1S/C10H14.3CH2O2.2ClH.Na.2Ru.H/c1-8(2)10-6-4-9(3)5-7-10;3*2-1-3;;;;;;/h4-8H,1-3H3;3*1H,(H,2,3);2*1H;;;;/q;;;;;;;+2;+3;/p-5

InChI key

QVXXTDGUSONXKR-UHFFFAOYSA-I

一般描述

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

应用

MCAT-53 is a recyclable ruthenium-containing catalyst for C–C coupling reactions in aqueous conditions. In contrast to Pd-catalyzed reactions, MCAT-53 achieves C–H-activated C–C coupling in water under ligand-free conditions, requiring no co-solvent, surfactant, or additional steps for activation. Bench- and air-stable, MCAT-53 will find wide utility in cost-effective and greener alternatives in pharmaceutical and manufacturing processes. This water-friendly catalyst is offered in collaboration with Chicago Discovery Solutions.
The catalyst has been successfully employed to synthesize a key intermediate of anacetrapib as a single regioisomer.

其他说明

Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Hetero-biaryl Compounds in Water through Aromatic C-H bond Activation

MCAT-53™: A Green Ruthenium Catalyst for Cross-Coupling & C–H Activation

法律信息

MCAT-53 is a trademark of Chicago Discovery Solutions LLC

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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访问文档库

Ruthenium (II)-catalyzed C-H bond activation and functionalization.
Arockiam PB, et al.
Chemical Reviews, 112(11), 5879-5918 (2012)
Palladium (II)-catalyzed C- H activation/C-C cross-coupling reactions: versatility and practicality.
Chen X, et al.
Angewandte Chemie (International Edition in English), 48(28), 5094-5115 (2009)
Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Hetero-biaryl Compounds in Water through Aromatic C-H bond Activation.
Mehta A, et al.
Organic Process Research & Development, 22(9), 1119-1130 (2018)
Greener solvents for ruthenium and palladium-catalysed aromatic C-H bond functionalisation.
Fischmeister C & Doucet H.
Green Chemistry, 13(4), 741-753 (2011)
Key green chemistry research areas-a perspective from pharmaceutical manufacturers.
Constable DJ, et al.
Green Chemistry, 9(5), 411-420 (2017)

商品

MCAT- 53™ Catalyst for Ruthenium Formation

A recyclable, ligand-free ruthenium catalyst for C–H activation reactions and concomitant C–C bond formation in the presence of water.

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