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86734

Sigma-Aldrich

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸

≥97.0% (CHN)

别名:

DOTA

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About This Item

经验公式（希尔记法）:
C16H28N4O8 · xH2O
CAS号:
60239-18-1
分子量:
404.42 (anhydrous basis)
Beilstein:
1186987
MDL编号:
MFCD00068657
UNSPSC代码:
12352005
PubChem化学物质编号:
57653192
NACRES:
NA.22

质量水平

100

方案

≥97.0% (CHN)

表单

powder

官能团

carboxylic acid

SMILES字符串

OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

InChI key

WDLRUFUQRNWCPK-UHFFFAOYSA-N

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应用

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)是一种大环络合剂。
  • 它已用于通过螯合64Cu放射性同位素进行碳纳米管生物偶联物的放射性标记。
  • DOTA可被N-羟基琥珀酰亚胺基活化，进而与单克隆抗体偶联，用于临床放射免疫治疗。
  • 它可与钆形成配合物用作MRI造影剂。
  • DOTA肽偶联物的金属配合物可用作治疗用放射性药物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM0148
BCCJ4712
BCCD5753
BCBV9132
BCBP6598V

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