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86734

Sigma-Aldrich

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸

≥97.0% (CHN)

别名:

DOTA

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About This Item

经验公式（希尔记法）:
C16H28N4O8 · xH2O
CAS号:
60239-18-1
分子量:
404.42 (anhydrous basis)
Beilstein:
1186987
MDL编号:
MFCD00068657
UNSPSC代码:
12352005
PubChem化学物质编号:
57653192
NACRES:
NA.22

质量水平

100

方案

≥97.0% (CHN)

表单

powder

官能团

carboxylic acid

SMILES字符串

OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

InChI key

WDLRUFUQRNWCPK-UHFFFAOYSA-N

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应用

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)是一种大环络合剂。
  • 它已用于通过螯合64Cu放射性同位素进行碳纳米管生物偶联物的放射性标记。
  • DOTA可被N-羟基琥珀酰亚胺基活化，进而与单克隆抗体偶联，用于临床放射免疫治疗。
  • 它可与钆形成配合物用作MRI造影剂。
  • DOTA肽偶联物的金属配合物可用作治疗用放射性药物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
BCCM0148
BCCJ4712
BCCD5753
BCBV9132
BCBP6598V

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The synthesis and chelation chemistry of DOTA- peptide conjugates.
De Leon-Rodriguez LM and Kovacs Z
Bioconjugate Chemistry, 19(2), 391-402 (2007)
An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.
Lewis MR, et al.
Bioconjugate Chemistry, 12(2), 320-324 (2001)
B Klaan et al.
Der Radiologe, 59(8), 710-721 (2019-07-10)
The imaging of chondral pathologies is an essential part in the work-up of acute and chronic joint diseases. Besides conventional MR imaging, CT and MR arthrography are well-established methods in evaluating articular cartilage. The application of these techniques requires knowledge
Nicholas P van der Meulen et al.
Molecules (Basel, Switzerland), 25(20) (2020-10-18)
44Sc has favorable properties for cancer diagnosis using Positron Emission Tomography (PET) making it a promising candidate for application in nuclear medicine. The implementation of its production with existing compact medical cyclotrons would mean the next essential milestone in the
Luca Garbuio et al.
The journal of physical chemistry. B, 117(11), 3145-3153 (2013-02-28)
We present the first example of chemoselective site-specific spin labeling of a monomeric protein with two spectroscopically orthogonal spin labels: a gadolinium(III) chelate complex and a nitroxide radical. A detailed analysis of the performance of two commercially available Gd(III) ligands
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