推荐产品
质量水平
方案
98%
表单
powder
mp
274-276 °C (dec.) (lit.)
官能团
iodo
储存温度
2-8°C
SMILES字符串
IC1=CNC(=O)NC1=O
InChI
1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
KSNXJLQDQOIRIP-UHFFFAOYSA-N
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警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
A Jeltsch et al.
Journal of molecular biology, 285(3), 1121-1130 (1999-01-27)
DNA methyltransferases flip their target base out of the DNA helix. Here, we have investigated base flipping by wild-type EcoRV DNA methyltransferase (M.EcoRV) and five M.EcoRV variants (D193A, Y196A, S229A, W231R and Y258A). These variants bind to DNA and S-adenosylmethionine
Supaluk Prachayasittikul et al.
Molecules (Basel, Switzerland), 14(8), 2768-2779 (2009-08-25)
This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C(4)H(9), s-C(4)H(9), CH(2)C(6)H(11), CH(2)C(6)H(5)) together with N1,N3-disubstituted (R) analogs 8a-b (R = n-C(4)H(9), CH(2)C(6)H(11)). Their antimicrobial activity was
Doreen Dobritzsch et al.
The Journal of biological chemistry, 277(15), 13155-13166 (2002-01-18)
Dihydroprymidine dehydrogenase catalyzes the first and rate-limiting step in pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds. The three-dimensional structures of a binary complex with the inhibitor 5-iodouracil and two ternary complexes with NADPH and the inhibitors
Takanori Oyoshi et al.
Journal of the American Chemical Society, 125(6), 1526-1531 (2003-02-06)
DNA local conformations are thought to play an important biological role in processes such as gene expression by altering DNA-protein interactions. Although left-handed Z-form DNA is one of the best-characterized and significant local structures of DNA, having been extensively investigated
Xiaorong Sun et al.
Oncotarget, 6(33), 34732-34744 (2015-09-30)
Bortezomib, a novel proteasome inhibitor, has been approved for treating multiple myeloma and mantle cell lymphoma and studied pre-clinically and clinically for solid tumors. Preferential cytotoxicity of bortezomib was found toward hypoxic tumor cells and endothelial cells in vitro. The
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