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Merck
CN

808598

Sigma-Aldrich

CLAmP

别名:

N-Methoxy-N-methyl-1H-pyrrole-1-carboxamide, Heller-Sarpong Reagent

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About This Item

经验公式(希尔记法):
C7H10N2O2
分子量:
154.17
UNSPSC代码:
12352000
PubChem化学物质编号:

表单

liquid

折射率

n/D 1.510

密度

1.126 g/mL

储存温度

2-8°C

SMILES字符串

O=C(N(OC)C)N1C=CC=C1

InChI

1S/C7H10N2O2/c1-8(11-2)7(10)9-5-3-4-6-9/h3-6H,1-2H3

InChI key

NLSJGNBOCVXWHS-UHFFFAOYSA-N

应用

The CLAmP (Carbonyl Linchpin N, O-dimethylhydroxylamine pyrrole) reagent, reported by Sarpong and Heller, is a useful building block for the efficient synthesis of unsymmetrical ketones. CLAmP shows high versatility based on compatibility with both highly reactive, thermally unstable nucleophiles as well as less reactive stable nucleophiles. It reacts with Grignard reagents to form the corresponding Weinreb amides.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

230.0 °F

闪点(°C)

110 °C

法规信息

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历史批次信息供参考:

分析证书(COA)

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One-pot Unsymmetrical Ketone Synthesis Employing a Pyrrole-Bearing Formal Carbonyl Dication Linchpin Reagent.
Heller ST, et al.
Angewandte Chemie (International Edition in English), 54(34), 9839-9843 (2015)

相关内容

Professor Heller's research focuses on mild acylation reactions using carbonylimidazole-derived reagents.

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