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Merck
CN

803588

Sigma-Aldrich

BM(PEG)2 (1,8-双马来酰亚胺基-二甘醇)

别名:

1,2-Bis(2-maleimidoethoxy)ethane, 1,8-Bis(maleimido)-3,6-dioxaoctane

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About This Item

经验公式(希尔记法):
C14H16N2O6
分子量:
308.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.22

方案

≥90%

表单

powder

分子量

308.29

反应适用性

reagent type: cross-linking reagent

储存条件

desiccated

溶解性

water: soluble

运输

ambient

储存温度

2-8°C

SMILES字符串

O=C(C=CC1=O)N1CCOCCOCCN2C(C=CC2=O)=O

InChI

1S/C14H16N2O6/c17-11-1-2-12(18)15(11)5-7-21-9-10-22-8-6-16-13(19)3-4-14(16)20/h1-4H,5-10H2

InChI key

FERLGYOHRKHQJP-UHFFFAOYSA-N

一般描述

BM(PEG)2和BM(PEG)3是同双功能马来酰亚胺交联剂,用于巯基(-SH)之间的缀合。此类双马来酰亚胺交联剂通常用于探索和表征蛋白质结构(即寡聚化)或蛋白质相互作用。由于BM(PEG)2和BM(PEG)3具有相同的反应性,但长度不同,因此这些试剂和类似试剂在蛋白质低聚物位点之间形成交联或相互作用方面的相对成功可以帮助确定分子内和分子间的距离。

特点和优势

  • 反应基团:马来酰亚胺(两端)
  • 反应性基团:巯基
  • 长聚乙二醇化巯基-巯基交联剂,由马来酰亚胺基团和2-单元聚乙二醇间隔臂组成
  • PEG间隔臂提供独特的优势,包括增加溶解度、增加稳定性、降低聚集倾向和降低免疫原性
  • 具有确定结构和分子量的纯化合物,确保可重复的蛋白质修饰效果
  • 非常适合小分子或肽结合

注意

本品对水分敏感。小瓶包装在具有干燥剂的可重新密封袋中,以减少水分暴露。冷藏后,打开前将小瓶平衡至室温,以减少小瓶内的冷凝。制作新鲜溶液。不建议储存储备液。使用后,将小瓶放回可重新密封的袋中。关闭袋子并将产品存放在建议的温度下。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

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