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Merck
CN

79421

Sigma-Aldrich

磷腈碱P4-t-Bu 溶液

~0.8 M in hexane

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别名:
1-丁基-4,4,4-三(二甲基氨基)-2,2-双[三(二甲基氨基)-膦亚基氨基]-2λ5,4λ5-链二(磷腈)
经验公式(希尔记法):
C22H63N13P4
分子量:
633.72
Beilstein:
5784423
MDL编号:
UNSPSC代码:
12352001
PubChem化学物质编号:
NACRES:
NA.22

形式

liquid

质量水平

浓度

~0.8 M in hexane

密度

0.850-0.875 g/mL at 20 °C

SMILES字符串

CN(C)P(=NP(=NC(C)(C)C)(N=P(N(C)C)(N(C)C)N(C)C)N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C

InChI

1S/C22H63N13P4/c1-22(2,3)23-36(24-37(27(4)5,28(6)7)29(8)9,25-38(30(10)11,31(12)13)32(14)15)26-39(33(16)17,34(18)19)35(20)21/h1-21H3

InChI key

NSRBCQCXZAYQHF-UHFFFAOYSA-N

注意

从溶液中结晶出来的产物,可在加热至40°C时再溶解。

其他说明

极强、受阻、中性的氮碱;大概比DBU[pKa (DMSO)30.25]的碱性强1018倍。水解稳定,不受烷基化剂影响;用于烯醇化物的形成和立体选择性烷基化的碱试剂

警示用语:

Danger

危险分类

Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 1 Inhalation - STOT SE 3

靶器官

Central nervous system, Nervous system

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

危险化学品

分析证书(COA)

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Saurabh Mehta et al.
The Journal of organic chemistry, 84(9), 5492-5503 (2019-04-16)
Phosphazene superbase P4- t-Bu mediated iodoaminocyclization of 2-(1-alkynyl)benzamides is reported. The reaction works under ambient conditions and instantaneously results in the synthesis of isoindolin-1-ones in 65-97% yields, in a regio- and stereoselective manner. The exclusive formation of products with Z-geometry
A. Solladie-Cavallo et al.
Tetrahedron Letters, 43, 415-415 (2002)
George A Kraus et al.
Bioorganic & medicinal chemistry letters, 19(19), 5539-5542 (2009-09-05)
Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma.
H.T. Mamdani, R.C. Hartley
Tetrahedron Letters, 41, 7417-7417 (2000)
R. Schwesinger et al
Angewandte Chemie (International Edition in English), 105, 1420-1420 (1993)

商品

Phosphazene base reagents are available as monomeric (P1 and BEMP), dimeric (P2), and tetrameric (P4) bases with different side chains to control their sterical hindrance.

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