所有图片(3)
About This Item
经验公式（希尔记法）:
C4H4F3NaO2S
分子量:
196.12
MDL编号:
UNSPSC代码:
12352101
PubChem化学物质编号:
NACRES:
NA.22
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表单
solid
质量水平
反应适用性
reaction type: C-C Bond Formation
reagent type: catalyst
reaction type: C-H Activation
mp
287-292 °C
官能团
fluoro
sulfinic acid
SMILES字符串
[O-]S(C1(CC1)C(F)(F)F)=O.[Na+]
InChI
1S/C4H5F3O2S.Na/c5-4(6,7)3(1-2-3)10(8)9;/h1-2H2,(H,8,9);/q;+1/p-1
InChI key
IZLDENBRBYPDNY-UHFFFAOYSA-M
应用
TFCS-Na is a diversification reagent for the C-H Functionalization of several classes of heterocycles. This reagent installs the trifluoromethylcyclopropyl group, which was recently reported to increase metabolic stability compared to compounds containing the tert-butyl group.
Simple Sulfinate Synthesis Enables C-H Trifluoromethylcyclopropanation
Simple Sulfinate Synthesis Enables C-H Trifluoromethylcyclopropanation
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
David Barnes-Seeman et al.
ACS medicinal chemistry letters, 4(6), 514-516 (2014-06-06)
Susceptibility to metabolism is a common issue with the tert-butyl group on compounds of medicinal interest. We demonstrate an approach of removing all the fully sp(3) C-Hs from a tert-butyl group: replacing some C-Hs with C-Fs and increasing the s-character
商品
Rapidly diversify (hetero)aromatic scaffolds for chemical industry needs amid resource and time constraints, ensuring efficiency.
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