766305
Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite
95%
别名:
Bis(2-cyanoethoxy)(diisopropylamino)phosphine, Bis(2-cyanoethoxy)-N,N-diisopropylaminophosphine
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关于此项目
经验公式（希尔记法）:
C12H22N3O2P
化学文摘社编号:
分子量:
271.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
95%
Form:
liquid
产品名称
Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite, 95%
InChI
1S/C12H22N3O2P/c1-11(2)15(12(3)4)18(16-9-5-7-13)17-10-6-8-14/h11-12H,5-6,9-10H2,1-4H3
SMILES string
CC(C)N(C(C)C)P(OCCC#N)OCCC#N
InChI key
LDHWBEHZLFDXCU-UHFFFAOYSA-N
assay
95%
form
liquid
refractive index
n20/D 1.465
density
1.039 g/mL at 25 °C
storage temp.
−20°C
Quality Level
Application
Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite may be used as a phosphitylating agent during the multi-step synthesis of (-)-1L-chiro-inositol 2,3,5-trisphosphate starting from L-quebrachitol.
General description
Useful phosphorylating reagent used in oligonucleotide synthesis for adding a terminal phosphate group to the 3′ or 5′ hydroxyl.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
165.0 °F
flash_point_c
73.9 °C
Inhibition of glutamate carboxypeptidase by phosphoryl and thiophosphoryl derivatives of glutamic and 2-hydroxyglutaric acid.
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Synthesis from quebrachitol of 1L-chiro-inositol 2, 3, 5-trisphosphate, an inhibitor of the enzymes of 1D-myo-inositol 1, 4, 5-trisphosphate metabolism.
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Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.
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Proceedings of the National Academy of Sciences of the USA, 86(24), 9702-9706 (1989)
Marek R Baranowski et al.
Nucleic acids research, 48(15), 8209-8224 (2020-06-10)
The high sensitivity of 19F nucleus to changes in the chemical environment has promoted the use of fluorine-labeled molecular probes to study structure and interactions of nucleic acids by 19F NMR. So far, most efforts have focused on incorporating the
Seigo Nagata et al.
Nucleic acids research, 38(21), 7845-7857 (2010-07-28)
Though medicines that target mRNA are under active investigation, there has been little or no effort to develop mRNA itself as a medicine. Here, we report the synthesis of a 130-nt mRNA sequence encoding a 33-amino-acid peptide that includes the
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