物料
PEG 5000
质量水平
形式
dispersion in H2O
nanoparticles
包装
poly bottle of 1 mL
OD
50
直径
5 nm
pH值（酸碱度）
6.0-8.0 (25 °C)
溶解性
water: miscible
密度
1.00 g/cm3
λmax
515 nm
官能团
amine
储存温度
2-8°C
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一般描述
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.
应用
功能化颗粒已广泛用于研究纳米颗粒的细胞摄取和靶向药物递送。
Several other specific applications have been listed below:
- Since AuNPs adhere to cell membranes, they can be used in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies
- AuNPs may also be used in photothermal therapy and radiotherapy.
- Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
- They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.
特点和优势
- Negatively charged siRNA-PEG complex which is attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
- Decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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