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Merck
CN

765139

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG average Mn 5,000, PLGA Mn 7,000

别名:

PEG-PLGA, mPEG-b-PLGA

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关于此项目

线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
12162002

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产品名称

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）, PEG average Mn 5,000, PLGA Mn 7,000

form

solid

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 5,000
PLGA Mn 7,000
average Mn 12,000 (total)

degradation timeframe

1-4 weeks

transition temp

Tg 24 °C
Tm 38-43 °C

PDI

<2.0

storage temp.

2-8°C

Quality Level

100

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相关类别

Application

可用于合成靶向纳米粒子，从而用于差异递送和控释药物。
形成“隐形”聚乙二醇化微粒

Features and Benefits

  • 良好的生物相容性、低免疫原性和良好的降解性。
  • 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。

General description

两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的，另一个是疏水的。这些大分子溶于水介质时具有自组装的特性。PEG-PLGA是最常用于药物递送应用的可生物降解的两亲嵌段共聚物之一。PEG是亲水部分，PLGA是疏水部分。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ1992
MKCV2202
MKCQ8258
MKCG9123
MKCG9125

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Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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