一般描述
聚乙烯亚胺（线性）是一种用途广泛的阳离子聚合物，具有较高的转染效率。它可用作基因传递试剂。这是一种非脂质聚阳离子，可用于将寡核苷酸和质粒转染至体内和体外细胞。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
Wiseman JW, et al.
Gene Therapy, 10(19), 1654-1654 (2003)
Bromodomain and extra-terminal (BET) protein inhibitors suppress chondrocyte differentiation and restrain bone growth
Niu N, et al.
The Journal of biological chemistry, 291(52), 26647-26657 (2016)
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou S, et al.
The journal of gene medicine, 2(2), 128-134 (2000)
Dae Hee Lee et al.
Biomaterials, 171, 34-45 (2018-04-22)
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative.
Marie-Elise Bonnet et al.
Pharmaceutical research, 25(12), 2972-2982 (2008-08-19)
The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for nucleic acid delivery due to
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Delivery of Nucleic Acids Using Polymers
Gene therapy has become one of the most discussed techniques in biomedical research in recent years.
Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.
CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.
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