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Merck
CN
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文件

安全信息

764817

Sigma-Aldrich

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1100-1000-1100), lactide:glycolide 75:25

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别名:
PLGA-PEG-PLGA
UNSPSC代码:
12162002
NACRES:
NA.23

描述

typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)

质量水平

100

形式

semisolid

投料比

lactide:glycolide 75:25

分子量

PEG average Mn 1,000
PLGA average Mn 2,200
average Mn (1100-1000-1100)

降解时间线

2-3 weeks

转变温度

Tm 230-235 °C

PDI

<2.0

储存温度

2-8°C

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相关类别

一般描述

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

应用

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

特点和优势

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Zhimei Song et al.
Journal of colloid and interface science, 354(1), 116-123 (2010-11-04)
The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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