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Merck
CN

764779

聚（乙二醇）甲醚- 嵌段 -聚（ D , L 丙交酯）

PEG average Mn 2,000, PDLLA average Mn 2,000

别名:

PEG-PDLLA

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关于此项目

NACRES:
NA.23
UNSPSC Code:
12162002

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产品名称

聚（乙二醇）甲醚- 嵌段 -聚（ D , L 丙交酯）, PEG average Mn 2,000, PDLLA average Mn 2,000

description

n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)

form

pellets

mol wt

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

degradation timeframe

2-4 weeks

transition temp

Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)

PDI

≤1.4

storage temp.

2-8°C

Quality Level

100

相关类别

Application

用作控制和靶向释放疏水性抗癌药物的载体。
药物的水溶性

Features and Benefits

  • 良好的生物相容性、低免疫原性和良好的降解性。
  • 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。

General description

嵌段共聚物胶束广泛用于药物递送领域。PEG-PDLLA是一种可生物降解的聚合物胶束，可用作疏水性药物（如紫杉醇）的载体。PEG是亲水性部分，PDLLA是疏水性部分，后者形成负载疏水性药物的胶束核心。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCS6562
MKCM3361
MKCJ7857
MKCG4708
MKCD4773

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Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

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