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Merck
CN
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文件

764779

Sigma-Aldrich

聚（乙二醇）甲醚- 嵌段 -聚（ D , L 丙交酯）

PEG average Mn 2,000, PDLLA average Mn 2,000

别名:

PEG-PDLLA

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About This Item

UNSPSC代码:
12162002
NACRES:
NA.23

描述

n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)

质量水平

100

形式

pellets

分子量

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

降解时间线

2-4 weeks

转变温度

Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)

PDI

≤1.4

储存温度

2-8°C

相关类别

一般描述

嵌段共聚物胶束广泛用于药物递送领域。PEG-PDLLA是一种可生物降解的聚合物胶束，可用作疏水性药物（如紫杉醇）的载体。PEG是亲水性部分，PDLLA是疏水性部分，后者形成负载疏水性药物的胶束核心。

应用

用作控制和靶向释放疏水性抗癌药物的载体。
药物的水溶性

特点和优势

  • 良好的生物相容性、低免疫原性和良好的降解性。
  • 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to

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