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764760

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG average Mn 2,000, PLGA average Mn 11,500

别名:

PEG-PLGA, mPEG-b-PLGA

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About This Item

线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC代码:
12162002
NACRES:
NA.23

表单

pellets

质量水平

100

投料比

lactide:glycolide 50:50

分子量

PEG average Mn 2,000
PLGA average Mn 11,500
average Mn 13,500 (total)

降解时间线

1-4 weeks

转变温度

Tm 298-303 °C
Tg 40 °C (PDLLA block)
Tg 6 °C (PEG block)

PDI

≤2.0

储存温度

2-8°C

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相关类别

一般描述

两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的而另一种是疏水的。这些大分子在溶于水性介质时具有自组装的特性。PEG-PLGA是于药物递送应用的最常见可生物降解两亲嵌段共聚物之一。PEG是亲水部分而PLGA是疏水部分。

应用

用于合成用于药物差异递送和受控释放的靶向纳米颗粒。

特点和优势

  • 良好的生物相容性，低免疫原性和良好的可降解性。
  • 可通过改变嵌段共聚物链段的尺寸以适合特定应用而轻松对属性进行调节。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCT5920
MKCQ9446
MKCS3661
MKCP0961
MKCG9119

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Che-Ming Jack Hu et al.
International journal of nanomedicine, 13, 8579-8593 (2018-12-28)
Influenza virus infections are a major public health concern worldwide. Conventional treatments against the disease are designed to target viral proteins. However, the emergence of viral variants carrying drug-resistant mutations can outpace the development of pathogen-targeting antivirals. Diphyllin and bafilomycin
Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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