跳转至内容
Merck
CN
所有图片(1)

文件

764760

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG average Mn 2,000, PLGA average Mn 11,500

登录查看公司和协议定价
所有图片(1)
别名:
PEG-PLGA, mPEG-b-PLGA
线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC代码:
12162002
NACRES:
NA.23

形式

pellets

质量水平

100

投料比

lactide:glycolide 50:50

分子量

PEG average Mn 2,000
PLGA average Mn 11,500
average Mn 13,500 (total)

降解时间线

1-4 weeks

转变温度

Tm 298-303 °C
Tg 40 °C (PDLLA block)
Tg 6 °C (PEG block)

PDI

≤2.0

储存温度

2-8°C

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的而另一种是疏水的。这些大分子在溶于水性介质时具有自组装的特性。PEG-PLGA是于药物递送应用的最常见可生物降解两亲嵌段共聚物之一。PEG是亲水部分而PLGA是疏水部分。

应用

用于合成用于药物差异递送和受控释放的靶向纳米颗粒。

特点和优势

  • 良好的生物相容性，低免疫原性和良好的可降解性。
  • 可通过改变嵌段共聚物链段的尺寸以适合特定应用而轻松对属性进行调节。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Che-Ming Jack Hu et al.
International journal of nanomedicine, 13, 8579-8593 (2018-12-28)
Influenza virus infections are a major public health concern worldwide. Conventional treatments against the disease are designed to target viral proteins. However, the emergence of viral variants carrying drug-resistant mutations can outpace the development of pathogen-targeting antivirals. Diphyllin and bafilomycin
Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

商品

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门