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Merck
CN
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文件

764752

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG average Mn 5,000, PLGA Mn 55,000

别名:

PEG-PLGA, mPEG-b-PLGA, mPEG-b-PLGA

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About This Item

线性分子式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC代码:
12162002
NACRES:
NA.23

描述

typical PEG PDI < 1.1; overall PDI < 2.5

质量水平

100

形式

pellets

投料比

lactide:glycolide 50:50

分子量

PEG average Mn 5,000
PLGA Mn 55,000
average Mn 60,000 (total)

降解时间线

1-4 weeks

转变温度

Tg 10 °C(lit.)
Tm 254-259 °C

PDI

<1.2

储存温度

2-8°C

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相关类别

一般描述

两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的，另一个是疏水的。这些大分子溶于水介质时具有自组装的特性。PEG-PLGA是最常用于药物递送应用的可生物降解的两亲嵌段共聚物之一。PEG是亲水部分，PLGA是疏水部分。

应用

可用于合成靶向纳米粒子，从而用于差异递送和控释药物。

特点和优势

  • 良好的生物相容性、低免疫原性和良好的降解性。
  • 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Hunter Bachman et al.
Lab on a chip, 20(7), 1238-1248 (2020-02-28)
Whether reagents and samples need to be combined to achieve a desired reaction, or precise concentrations of solutions need to be mixed and delivered downstream, thorough mixing remains a critical step in many microfluidics-based biological and chemical assays and analyses.
Thermosensitive self-assembling block copolymers as drug delivery systems
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymers (Basel, Switzerland), 3(2), 779-811 (2011)
Sara Moufarrij et al.
Scientific reports, 10(1), 3470-3470 (2020-02-28)
Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

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