形式
solid
质量水平
反应适用性
reaction type: click chemistry
reagent type: cross-linking reagent
mp
36-41 °C
官能团
NHS ester
alkyne
储存温度
−20°C
SMILES字符串
C#CCOCCC(ON1C(CCC1=O)=O)=O
InChI
1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2
InChI key
WKIKHHMUNOVQLD-UHFFFAOYSA-N
应用
炔丙基-N-羟基琥珀酰亚胺酯可用作通过化学蛋白质组学方法鉴定亲核可配位热点的工具。
炔丙基-NHS酯是一种胺反应性试剂，用于肽、抗体、胺包被表面等的衍生化，具有一个末端炔烃。通过铜催化的叠氮化物-炔烃点击化学，炔烃可以与含叠氮化合物或生物分子反应，得到稳定的三唑键。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.
Ward CC, et al.
ACS Chemical Biology (2017)
Qianyun Zhang et al.
ACS nano, 12(10), 10473-10485 (2018-10-06)
Multivalent presentation of ligands on nanoparticles (NPs) is considered a general strategy for enhancing receptor binding and activation through amplification of ligand-receptor interactions within the footprint of the individual NPs. The spatial clustering of ligand-functionalized NPs represents an additional, less
Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease
Zhu X, et al.
ACS Applied Materials & Interfaces (2017)
Yi Yu et al.
Nature chemical biology, 16(4), 387-390 (2019-12-25)
Here, we report a rapid CRISPR-Cas9-mediated gene knock-in strategy that uses Cas9 ribonucleoprotein and 5'-modified double-stranded DNA donors with 50-base-pair homology arms and achieved unprecedented 65/40% knock-in rates for 0.7/2.5 kilobase inserts, respectively, in human embryonic kidney 293T cells. The identified
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