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Merck
CN

760676

Sigma-Aldrich

二苄环辛基-PEG4-马来酰亚胺

for Copper-free Click Chemistry

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别名:
DBCO-PEG4-马来酰亚胺
经验公式(希尔记法):
C36H42N4O9
分子量:
674.74
MDL编号:
UNSPSC代码:
12161502
PubChem化学物质编号:
NACRES:
NA.22

形式

solid

反应适用性

reaction type: click chemistry
reagent type: cross-linking reagent

官能团

maleimide

储存温度

−20°C

SMILES字符串

O=C(CCNC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C36H42N4O9/c41-32(14-18-39-34(43)11-12-35(39)44)38-17-20-47-22-24-49-26-25-48-23-21-46-19-15-33(42)37-16-13-36(45)40-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)40/h1-8,11-12H,13-27H2,(H,37,42)(H,38,41)

InChI key

VVFZXPZWVJMYPX-UHFFFAOYSA-N

应用

马来酰亚胺功能化环辛炔衍生物,用于将环辛炔基团掺入含巯基化合物或生物分子。环辛烯在促进无铜叠氮炔环加成反应中是有用的。这种二苯并环辛炔将与叠氮官能化化合物或生物分子反应,而不需要 Cu (I) 催化剂产生稳定的三唑键。PEG 亲脂性间隔物有助于减少标记生物分子时的聚集和沉淀问题。
应用包括:
  • 蛋白-肽结合物
  • 抗体酶或抗体-药物偶联物
  • 蛋白或肽-寡核苷酸结合物
  • 表面改性

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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