760668
二苯并环辛基马来酰亚胺
for Copper-free Click Chemistry
别名:
DBCO-马来酰亚胺
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关于此项目
经验公式（希尔记法）:
C25H21N3O4
分子量:
427.45
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
产品名称
二苯并环辛基马来酰亚胺, for Copper-free Click Chemistry
InChI
1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29)
SMILES string
O=C(N1CCC(NCCC(N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4)=O)=O)C=CC1=O
InChI key
NHFQNAGPXIVKND-UHFFFAOYSA-N
form
solid
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
functional group
maleimide
storage temp.
−20°C
Quality Level
Application
马来酰亚胺功能化环辛炔衍生物，用于将环辛炔基团掺入含巯基化合物或生物分子。环辛烯在促进无铜叠氮炔环加成反应中是有用的。这种二苯并环辛炔将与叠氮官能化化合物或生物分子反应，而不需要 Cu (I) 催化剂产生稳定的三唑键。
应用包括：
应用包括：
- 蛋白-肽结合物
- 抗体酶或抗体-药物偶联物
- 蛋白或肽-寡核苷酸结合物
- 表面改性
A comparative study of bioorthogonal reactions with azides
Agard, N.; et al.
ACS Chemical Biology, 10, 644-648 (2006)
Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells
Cal PM, et al.
Chemical Communications (Cambridge, England), 53(2), 368-371 (2017)
Highly robust and optimized conjugation of antibodies to nanoparticles using quantitatively validated protocols.
Jeong S, et al.
Nanoscale, 9(7), 2548-2555 (2017)
Hansjörg Götzke et al.
Nature communications, 10(1), 4403-4403 (2019-09-29)
Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while
Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.
Xinghai Ning et al.
Angewandte Chemie (International ed. in English), 47(12), 2253-2255 (2008-02-16)
商品
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
无铜点击化学是点击化学的一种替代方法，可在较低的活化屏障下进行，且没有细胞毒性过渡金属催化剂。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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