InChI key
OJQNRNQELNLWHH-UHFFFAOYSA-N
InChI
1S/C3H6FNO2/c4-2(1-5)3(6)7/h2H,1,5H2,(H,6,7)
SMILES string
NCC(F)C(O)=O
assay
95%
form
solid
mp
240-245 °C
functional group
amine, carboxylic acid, fluoro
Quality Level
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A S Dzik-Jurasz et al.
Magnetic resonance in medicine, 44(4), 516-520 (2000-10-12)
The hepatobiliary distribution of 5-fluorouracil (5FU) catabolites was investigated in nine patients. Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients
Bruno Reigner et al.
Cancer chemotherapy and pharmacology, 52(3), 193-201 (2003-06-05)
Capecitabine (Xeloda) is a novel, oral fluoropyrimidine carbamate rationally designed to generate 5-fluorouracil (5-FU) preferentially in tumor tissue via a three-step enzymatic cascade. The objective of this study was to compare the pharmacokinetics of capecitabine and its metabolites in Japanese
Woo Young Kim et al.
Cancer science, 98(10), 1604-1608 (2007-08-09)
We studied whether total gastrectomy for gastric cancer would affect the pharmacokinetics of 5-fluorouracil (5-FU) and its degradation products, such as dihydrouracil (FUH(2)) and alpha-fluoro-beta-alanine (FBAL), after oral administration of the fluorouracil derivative S-1, composed of tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP; a
K Okuno et al.
Cancer chemotherapy and pharmacology, 42(4), 341-344 (1998-09-23)
The aim of this study was to identify the route of administration of 5-FU with the greatest pharmacological advantage in a rat model using non-invasive in vivo 19F nuclear magnetic resonance (NMR) spectroscopy. 5-FU (50 mg/kg) was administered to anesthetized
S Ndaw et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(27), 2630-2634 (2010-03-09)
A new sensitive and specific HPLC-MS/MS method for the determination of α-fluoro-β-alanine (FBAL), the main metabolite of the antineoplastic drug 5-fluorouracil (5-FU), in urine for the biological monitoring survey of health care workers exposed to 5-FU is described. This procedure
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