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检测方案
95%
形式
solid
mp
38-44 °C
储存温度
−20°C
SMILES字符串
COC(=O)n1ccnc1
InChI
1S/C5H6N2O2/c1-9-5(8)7-3-2-6-4-7/h2-4H,1H3
InChI key
JQCPMLVMNQVRCC-UHFFFAOYSA-N
一般描述
1H-咪唑-1-甲酸甲酯是由Heller和Sarpong开发的一种试剂，用于羧酸的化学选择性酰胺化和酯化。
应用
1H-咪唑-1-羧酸甲酯可用于制备氟β酮酯，其是用于合成氟化L-卡比多巴衍生物的前体。
WGK
WGK 3
闪点(°F)
194.0 °F
闪点(°C)
90 °C
Fluorous l-Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity
Granados A, et al.
The Journal of Organic Chemistry, 83(1), 303-313 (2018)
Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas
Heller ST and Sarpong R
Organic Letters, 12(20), 4572-4575 (2010)
相关内容
Professor Heller and coworkers are engaged in the development of mild and chemoselective acylation reactions using carbonylazole-derived reagents. To that end, they have developed a suite of carbonylimidazole derivatives for facile and chemoselective esterification (MImC, etc.) and amidation (WImC) of carboxylic acids, in collaboration with Professor Richmond Sarpong.
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