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Merck
CN
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文件

739960

Sigma-Aldrich

Resomer® RG 505，聚（D,L-丙交酯-co-乙交酯）

ester terminated, Mw 54,000-69,000

别名:

PLGA, RESOMER® RG 505

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
26780-50-7
UNSPSC代码:
12162002
NACRES:
NA.23

质量水平

100

形式

amorphous

投料比

lactide:glycolide 50:50

分子量

Mw 54,000-69,000

降解时间线

<3 months

粘度

0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

转变温度

Tg 48-52 °C

储存温度

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

一般描述

聚 （丙交酯-乙交酯）（PLGA）是一种可生物降解的聚合物，用于制备聚合物微球。这些聚合物在体内通过其酯骨架水解为无毒产物而降解，这些无毒产物可由肾脏排出，或通过生物化学途径分解为CO2 和水。PLGA微球被广泛应用于包裹药物分子，并可用作长效缓释药物制剂。

应用

聚 （丙交酯-乙交酯）（PLGA）可用于制造缓释药物递送体系，例如，它可用于包裹抗炎亲脂药物阿托伐他汀。

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Aline M Thomas et al.
Biomaterials, 34(9), 2213-2220 (2013-01-08)
Bridges implanted into the injured spinal cord function to stabilize the injury, while also supporting and directing axon growth. The architecture of the bridge is critical to its function, with pores to support cell infiltration that integrates the implant with
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