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Merck
CN
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739944

Sigma-Aldrich

Resomer® RG 504，聚（D,L-丙交酯-co-乙交酯）

lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000

别名:

PLGA

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
26780-50-7
UNSPSC代码:
12162002
NACRES:
NA.23

质量水平

100

形式

amorphous

投料比

lactide:glycolide 50:50

分子量

Mw 38,000-54,000

降解时间线

<3 months

粘度

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

转变温度

Tg 46-50 °C

储存温度

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

应用

Resomer® RG 504, 聚（ᴅ,ʟ-丙交酯-co-乙交酯）可用于制备 聚合物纳米颗粒， 其是 天然抗癌物质的有效载体。

聚（D, L-丙交酯-co-乙交酯）微球可用于制造凝血酶的止血给药设备。

特点和优势

控释生物活性剂，缝线和生物可吸收的植入装置

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
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