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Merck
CN

725668

Sigma-Aldrich

N-羟基琥珀酰亚胺 (NHS) 酯封端的聚(N-异丙基丙烯酰胺)

average Mn 2,000

别名:

NIPAM 聚合物, PNIPAM-NHS, 功能化聚(N-异丙基丙烯酰胺), 功能化聚丙烯酰胺, 聚(N-异丙基丙烯酰胺), 聚丙烯酰胺

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About This Item

线性分子式:
(C6H11NO)n SCH2CH2COO(C4H4NO2)
UNSPSC代码:
12162002
NACRES:
NA.23

形式

powder

质量水平

分子量

average Mn 2,000

mp

>300 °C

相关类别

应用

用于开发热敏涂层微/纳米材料的新型聚合物,包括热响应性聚合物药物递送系统。 NHS酯官能团可用于使多种生物分子(如酶)与聚合物链偶联。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Rzaev, Z.M.O.; Dincer, S.; Piskin, E.
Progress in Polymer Science, 32, 534-534 (2007)
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a
Chung, J. E.; Yokoyama, M.; Suzuki, K.; Aoyagi, T.; Sakurai, Y.; Okano, T.
Colloids and Surfaces, B: Biointerfaces, 9, 37-37 (1997)
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in

商品

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

组织工程已成为治疗受损或患病的器官和组织(例如血管和尿囊)的关键治疗工具。

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

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