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Merck
CN

724459

Sigma-Aldrich

羧酸封端的聚(N-异丙基丙烯酰胺)

average Mn 10,000

别名:

NIPAM 聚合物, PNIPAM-COOH, 功能化聚(N-异丙基丙烯酰胺), 功能化聚丙烯酰胺, 聚(N-异丙基丙烯酰胺), 聚丙烯酰胺

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About This Item

线性分子式:
(C6H11NO)nSCH2CH2CO2H
UNSPSC代码:
12162002
NACRES:
NA.23

形式

powder

质量水平

分子量

average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI)
average Mn 10,000

mp

>300 °C

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应用

用于开发表面热敏性的微/纳米材料(包括热响应聚合物给药系统)的新型聚合物。羧酸官能团可用于以共轭的方式向聚合物链引入多种生物分子。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Shahrzad Rayatpisheh et al.
Macromolecular bioscience, 12(7), 937-945 (2012-04-27)
A new method for ultrathin grafting of pNIPAm on PDMS surfaces is introduced that employs plasma activation of the surface followed by thermal polymerization. This method is optimized for human primary SMC attachment and subsequent intact cell sheet detachment by
A C C Rotzetter et al.
Advanced materials (Deerfield Beach, Fla.), 24(39), 5352-5356 (2012-08-31)
Buildings can be effectively cooled by a bioinspired sweating-like action based on thermoresponsive hydrogels (PNIPAM), which press out their stored water when exceeding the lower critical solution temperature. The surface temperature is reduced by 15 °C compared to that of
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
G Chen et al.
Nature, 373(6509), 49-52 (1995-01-05)
There are many potential applications of 'intelligent' aqueous polymer systems in medicine, biotechnology, industry and in environmental problems. Many of these polymer systems undergo reversible phase transitions--for example, abrupt changes in volume--in response to external stimuli such as temperature, pH

商品

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

组织工程已成为治疗受损或患病的器官和组织(例如血管和尿囊)的关键治疗工具。

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

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