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Merck
CN

719927

Resomer® RG 756 S，聚（D,L-丙交酯-co-乙交酯）

ester terminated, lactide:glycolide 75:25, Mw 76,000-115,000

别名:

RESOMER® RG 756 S, PLGA

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关于此项目

线性分子式:
[C3H4O2]x[C2H2O2]y
化学文摘社编号:
26780-50-7
MDL number:
MFCD00131930
UNSPSC Code:
12162002
NACRES:
NA.23

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产品名称

Resomer® RG 756 S，聚（D,L-丙交酯-co-乙交酯）, ester terminated, lactide:glycolide 75:25, Mw 76,000-115,000

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

form

amorphous

feed ratio

lactide:glycolide 75:25

mol wt

Mw 76,000-115,000

degradation timeframe

<6 months

viscosity

0.71-1.0 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

Tg 49-55 °C

storage temp.

2-8°C

Quality Level

200

相关类别

Application

控制释放
聚(乳酸-共-乙醇酸)75:25共聚物可用于设计控制药物递送植入物。

Legal Information

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW7828
MKCW7829
MKCV6334
MKCV6333
BCCH5996

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An in-situ forming implant formulation of naltrexone with minimum initial burst release using mixture of PLGA copolymers and ethyl heptanoate as an additive: In-vitro, ex-vivo, and in-vivo release evaluation.
Kamali H, et al.
Journal of drug delivery science and technology, 47, 95-105 (2018)
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
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