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质量水平
表单
amorphous
投料比
lactide:glycolide 50:50
分子量
Mw 7,000-17,000
降解时间线
<3 months
粘度
0.16-0.24 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
转变温度
Tg 42-46 °C
运输
wet ice
储存温度
2-8°C
应用
Resomer® RG 502可用于制备基于PLGA的纳米 药物递送系统，用于抗炎药物6-溴靛玉红-3′-甘油肟醚（6BIGOE）。
它还可用于制备盐酸纳洛酮递送的控制释放。
它还可用于制备盐酸纳洛酮递送的控制释放。
特点和优势
- 生物相容性
- 生物可降解
- 可加工成几乎任何形状和尺寸
- 机械性能可调
法律信息
Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
商品
Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.
商业生物材料已停滞不前超过30年的时间，因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局（FDA）批准的记录，一直在可吸收生物材料领域占据主导地位。
Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.
AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.
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