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Merck
CN
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文件

712957

Sigma-Aldrich

tert-Butyl (S)-2-pyrrolidone-5-carboxylate

≥98% (GC)

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别名:
tert-Butyl (S)-5-oxo-2-pyrrolidinecarboxylate, tert-Butyl 5-oxo-L-prolinate, tert-Butyl L-pyroglutamate
经验公式（希尔记法）:
C9H15NO3
CAS号:
35418-16-7
分子量:
185.22
Beilstein:
3590226
EC 号:
252-555-5
MDL编号:
MFCD06659481
UNSPSC代码:
12352005
PubChem化学物质编号:
329763163
NACRES:
NA.22

检测方案

≥98% (GC)

形式

powder

SMILES字符串

CC(C)(C)OC(=O)[C@@H]1CCC(=O)N1

InChI

1S/C9H15NO3/c1-9(2,3)13-8(12)6-4-5-7(11)10-6/h6H,4-5H2,1-3H3,(H,10,11)/t6-/m0/s1

InChI key

QXGSPAGZWRTTOT-LURJTMIESA-N

应用

tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:
  • As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.
  • In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.
  • As a starting material in the synthesis of radioligands [18F]IUR-1602 and [18F]IUR-1601, applicable for imaging of P2X7R, a therapeutic target for neuroinflammation.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F] IUR-1602
Gao M, et al.
Applied Radiation and Isotopes, 144(1), 10-18 (2019)
Synthesis and pharmacology of the potent angiotensin-converting enzyme inhibitor N-[1 (S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanyl-(S)-pyroglutamic acid
Johnson AL, et al.
Journal of medicinal chemistry, 28(11), 1596-1602 (1985)
Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F] IUR-1601
Gao M, et al.
Bioorganic & medicinal chemistry letters, 28(9), 1603-1609 (2018)
Potent orally active inhibitors of angiotensin-converting enzyme (ACE)
Imaki K, et al.
Chemical & Pharmaceutical Bulletin, 29(8), 2210-2214 (1981)
Indolizidine and quinolizidine alkaloids
Michael JP
Natural Product Reports, 24(1), 191-222 (2007)

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