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Merck
CN

700312

Sigma-Aldrich

氧化铁(II,III),磁性纳米颗粒 溶液

10 nm avg. part. size, 5 mg/mL in toluene

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别名:
磁性氧化铁纳米颗粒, 磁铁矿, 超顺磁氧化铁纳米颗粒
经验公式(希尔记法):
Fe3O4
CAS号:
分子量:
231.53
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.23

形式

nanoparticles
solution

质量水平

浓度

5 mg/mL in toluene

磁化

>45 emu/g (at ambient temperature under 4500 Oe)

平均零件尺寸

10 nm

粒径

9-11 nm (TEM; conforms)

密度

0.865 g/mL at 25 °C

SMILES字符串

O=[Fe].O=[Fe]O[Fe]=O

InChI

1S/3Fe.4O

InChI key

SZVJSHCCFOBDDC-UHFFFAOYSA-N

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一般描述

氧化铁(II、III)磁性纳米颗粒溶液(Fe3O4)是一种有机溶剂分散纳米颗粒溶液,可通过乙酰丙酮铁在2-吡咯烷酮热分解合成。基于其磁性能、颗粒大小和表面性质,它主要应用于生物医学领域。
含有<1.0% 油酸稳定配体。
浓度5mg/ml包括纳米晶体加配体的总重量。

应用

Fe3O4可用作肿瘤细胞的靶向和成像,应用于癌症治疗。它还可用于从新鲜全血中分离肿瘤细胞。此外,它还可用作药物传递系统和磁共振成像(MRI)的有效材料。

警示用语:

Danger

危险分类

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

45.0 °F

闪点(°C)

7.2 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品
易制毒化学品(3类)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What method is used to determine the size of the particles in Product 700312, Iron oxide?

    TEM used to check particle size. Light Scattering or similar methods are not utilized.

  6. How is the magnetization of Product 700312, Iron oxide, determined?

    Per the supplier, the magnetization is determined by using a Magnetic Susceptibility Balance.

  7. What is the purpose of the oleic acid in Product 700312, Iron oxide? Can it be removed?

    Per the manufacturer, the oleic acid allows the iron oxide nanoparticles to be soluble in the solvent (i.e. toluene).

  8. What is the coating thickness of oleic acid on product number 700312, 700320, and 700304, Iron oxide(II,III), magnetic nanoparticles solution?

    The suppliers of the magnetic iron oxide nanoparticles in toluene have indicated that the particles are essentially coated with a monolayer of oleic acid. Since the oleic acid is a long chain hydrocarbon there can exist some folding and irregular structure on the surface.  The suppliers estimate that one should add 1-2 nm to the particle size due to the presence of the oleic acid coating. From this, 1.5 nm is the closest approximation of coating thickness as provided by our suppliers.

  9. How should a sample of the Iron oxide(II,III), magnetic nanoparticles solution in toluene be prepared for analysis by transmission electron microscopy (TEM)?

    The particle size is determined by TEM.If the solution as provided is not diluted, a superlattice of multilayer nanocrystals will form on the grid, appearing to be an aggregate. The solution can be diluted with the same solvent that it was shipped in (toluene). A solution diluted to 0.1-0.5 mg/mL should be concentrated enough to get a nice picture. One drop per grid should be sufficient. (Since the solution is provided at a concentration of 5 mg/mL, this would be a 10- to 50-fold dilution.)After applying the sample to the grid, a drying time of a minimum of 10-15 minutes is recommended.After performing several successful dilutions and getting good results, the analyst will get a feel for the correct dilution just by judging the color and darkness of the diluted sample. If you see lone isolated dots in the TEM, then your sample is too dilute. If you cannot distinguish separate particles, it is too concentrated. Good record keeping will help to zero in on the best dilution factor for the type of picture that you want.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)
Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)

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