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方案
97%
表单
solid
mp
189-193 °C
官能团
aldehyde
nitro
SMILES字符串
[O-][N+](=O)c1cccc2[nH]cc(C=O)c12
InChI
1S/C9H6N2O3/c12-5-6-4-10-7-2-1-3-8(9(6)7)11(13)14/h1-5,10H
InChI key
CGXVTWQTGQAMMX-UHFFFAOYSA-N
应用
- reactant in synthesis of tryptophan dioxygenase inhibitors as potential anticancer immunomodulators
- reactant in synthesis of structural analogs of thaxtomin
- reactant in preparation of chromophores related to gold fluorescent protein
- reactant in preparation of brassinin and gramine derivatives
警示用语:
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
Synthesis, 7, 1103-1103 (2007)
Tetrahedron, 46, 6085-6085 (1990)
Australian Journal of Chemistry, 63, 813-813 (2010)
Heterocycles, 36, 2783-2783 (1993)
Journal of medicinal chemistry, 54(15), 5320-5334 (2011-07-06)
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase
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