推荐产品
质量水平
检测方案
≥89.0%
90%
形式
lumps
SMILES字符串
COc1ccc2nccc([C@H](NC(=S)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C4CC5CCN4C[C@@H]5C=C)c2c1
InChI
1S/C29H28F6N4OS/c1-3-16-15-39-9-7-17(16)10-25(39)26(22-6-8-36-24-5-4-21(40-2)14-23(22)24)38-27(41)37-20-12-18(28(30,31)32)11-19(13-20)29(33,34)35/h3-6,8,11-14,16-17,25-26H,1,7,9-10,15H2,2H3,(H2,37,38,41)/t16-,17-,25-,26-/m0/s1
InChI key
IQMKPBFOEWWDIQ-FRSFCCSCSA-N
应用
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea is a bifunctional cinchona organocatalyst, which can be used to synthesize:
- Stereoselective diaryl(nitro)butanone via enantioselective Michael addition of nitromethane to chalcones.
- Enantioselective β-amino acids via asymmetric Mannich reaction of malonates with aryl and alkyl imines.
- The synthesis of 3-indolylmethanamines by the reaction of indoles with imines via asymmetric Friedel-Crafts reaction.
- The enantioselective conjugate addition of active methylene compounds to enones to obtain the corresponding addition products.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
The Mannich reaction of malonates with simple imines catalyzed by bifunctional cinchona alkaloids: enantioselective synthesis of ?-amino acids
Journal of the American Chemical Society, 128(18), 6048-6049 (2006)
Asymmetric Friedel- Crafts reaction of indoles with imines by an organic catalyst
Journal of the American Chemical Society, 128(25), 8156-8157 (2006)
Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts
Organic Letters, 7(10), 1967-1969 (2005)
Organocatalytic enantioselective conjugate additions to enones
Journal of the American Chemical Society, 128(39), 12652-12653 (2006)
Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.
Angewandte Chemie (International ed. in English), 44(39), 6367-6370 (2005-09-02)
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